Micky van de Ven Brace Halts Everton's Run at New Home Ground
The Dutch defender emerged as the first defender to net two goals in a Premier League game for Spurs since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads home two times in opening period
The home side's Jake O'Brien has equalizer ruled after video check
Pape Matar Sarr scores final goal in dying moments
This loss is Everton's initial at their new ground
The Tottenham defender scored twice as Spurs prolonged their winning streak in away games in the Premier League and delivered the Toffees their initial loss at their new home.
Everton were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after 133 years at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman struck twice from set-pieces in the first half to place their strong form at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
Jake O'Brien thought he had levelled the tally five minutes after Van de Ven's first goal, directing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, missed a handful of chances, while the Italian goalkeeper made a succession of excellent stops to guarantee the London club went five matches on the road without defeat in the Premier League.
But the video assistant referee intervened, advising the match official to review the goal on the screen and the referee ruled that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win moves the manager's side into third place in the Premier League, a handful of points off north London rivals and leaders Arsenal.
Everton stay in 14th position and sit half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at each end of the field
After a drab midweek performance in the European competition against Monaco, where they managed a only attempts on goal, the manager chose Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being substituted for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the end.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder heading the ball back across the face of goal for an free Van de Ven to head home.
And Ven de Ven - filling in as captain in the Argentine's unavailability - added his next goal in first-half stoppage time as he outjumped the England keeper to nod in.
Van de Ven was just as impressive in defensive duties, partnering well with Kevin Danso as the pair dealt excellently with the numerous deliveries thrown their way by the opposition.
Toffees breakdown: Everton lacking finishing touch
The club's recent stadium had been a happy hunting ground, but it appears the novelty may have worn off slightly and supporters headed to the gates after Sarr's third for Spurs.
The end in Everton's winning streak at home will not be a massive concern for David Moyes, but their striker situation will be.
The forward and the other striker - the Everton's two recognised strikers - had scored only one league goal combined before the weekend's outing.
And they were unable to add to that poor tally on a damp and dreary evening on Merseyside.
Beto's performance was epitomized when he opted to bicycle-kick a clear chance from close range, despite having room and time to reposition for a more conventional shot that would have challenged Vicario.
Barry, as well, failed to make an impact after replacing the starter in the 65th minute.
It wasn't for a lack of chance. The majority of Everton's attacks came through the winger and Ndiaye, who relentlessly whipped dangerous balls into the Tottenham penalty area.
What next for both teams?
The Toffees: Moyes' men travel to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Spurs: Spurs travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.